Granulomatosis with Polyangiitis
Educational information. Individual clinical review of this presentation by Dr. Ehsan is not yet documented. It does not replace personal medical evaluation.
Source: MedlinePlus, National Library of Medicine. Read the original source
MedlinePlus data edition September 26, 2026. Imported September 27, 2026. These dates do not indicate a new clinical review of the article.
Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is a rare disease. It is a type of vasculitis, or inflammation of the blood vessels. The inflammation limits the flow of blood to important organs, causing damage. It can affect any organ, but it mainly affects the sinuses, nose, trachea (windpipe), lungs, and kidneys.
The cause of GPA is unknown. It can affect people at any age. Men and women are equally affected. It is more common in whites. Symptoms may include joint pain, weakness, tiredness, and cold symptoms such as a runny nose that doesn't get better. Doctors use blood tests, chest X-rays, and biopsies to diagnose GPA and rule out other causes of the symptoms.
Early treatment is important. Most people improve with medicines to slow or stop the inflammation.
Questions for your care team
General prompts to help prepare for your appointment.
- How does this information apply to my situation?
- Which symptoms or results need evaluation?
- Which tests are useful, and what can they tell us?
- What care options, benefits, and risks should we discuss?
- When should I seek urgent help, and whom should I call?
- When is follow-up, and how will we know whether the plan is working?
For a life-threatening emergency, call 911 in the U.S. or your local emergency number.
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