Melanoma
Educational information. Individual clinical review of this presentation by Dr. Ehsan is not yet documented. It does not replace personal medical evaluation.
Source: MedlinePlus, National Library of Medicine. Read the original source
MedlinePlus data edition September 26, 2026. Imported September 27, 2026. These dates do not indicate a new clinical review of the article.
Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. Most melanomas have a black or black-blue area. Melanoma may also appear as a new mole. It may be black, abnormal, or "ugly looking."
Thinking of "ABCDE" can help you remember what to watch for:
- Asymmetry - the shape of one half does not match the other
- Border - the edges are ragged, blurred or irregular
- Color - the color is uneven and may include shades of black, brown and tan
- Diameter - there is a change in size, usually an increase
- Evolving - the mole has changed over the past few weeks or months
Surgery is the first treatment of all stages of melanoma. Other treatments include chemotherapy and radiation, biologic, and targeted therapies. Biologic therapy boosts your body's own ability to fight cancer. Targeted therapy uses substances that attack cancer cells without harming normal cells.
NIH: National Cancer Institute
Symptoms, tests and care options
Further reading selected by MedlinePlus. Links open the original organizations’ websites.
- BRAF Genetic Test · National Library of Medicine
- Drugs Approved for Melanoma · National Cancer Institute
- Lymphoscintigraphy · Radiological Society of North America
- PDL1 (Immunotherapy) Tests · National Library of Medicine
- Treatment Option Overview (Melanoma) · National Cancer Institute
Questions for your care team
General prompts to help prepare for your appointment.
- How does this information apply to my situation?
- Which symptoms or results need evaluation?
- Which tests are useful, and what can they tell us?
- What care options, benefits, and risks should we discuss?
- When should I seek urgent help, and whom should I call?
- When is follow-up, and how will we know whether the plan is working?
For a life-threatening emergency, call 911 in the U.S. or your local emergency number.
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