CDH1 and your next conversation

What CDH1 means

CDH1 helps make E-cadherin, a protein that helps cells stay connected. Everyone has this gene. The exact genetic change and its classification determine what a result may mean.

What changes the discussion

Certain inherited pathogenic or likely pathogenic variants are associated with diffuse stomach cancer and lobular breast cancer. A finding in tumor tissue does not by itself establish an inherited condition. A variant of uncertain significance, or VUS, is not a confirmed harmful result and should not alone determine preventive surgery.

The next conversation

For a confirmed inherited harmful variant, a specialist team can discuss expert stomach surveillance, risk-reducing surgery, breast screening when relevant, and nutrition. The balance depends on the variant, age, family history and individual circumstances. This guide cannot calculate personal risk or choose a screening schedule.

Prepare for your genetics appointment

Bring the laboratory report and a family history with cancer types and ages at diagnosis to your clinician. Select the questions you want to discuss.

• What is the exact variant and its current classification?
• Was this an inherited-risk test or a tumor test? Is confirmation needed?
• How does my family history change the recommendations?
• Which surveillance and risk-reduction options apply to me?
• Who will explain potential benefits, limitations and long-term effects?
• Should relatives discuss testing, and who will track reclassification?

A conversation with family

You can ask your genetics team for a family letter that explains the confirmed finding and where relatives can seek counseling. Share only information you choose to share.